Technology

The core of the GMSbiotech technology platform is a very low cost and high throughput method to fabricate microarrays and other similar solid state devices for the analysis of many gene sites in parallel.

GMSbiotech microarrays are fabricated by covalent attachment of DNA fragments to specific sites on a surface to form an array of sites ("the microarray") that can independently engage in DNA hybridization analysis with a complex solution state DNA mixture of interest: each DNA site on the micro array performing a unique DNA hybridization test. The spontaneous assembly of an orderly DNA monolayer on the microarray surface and the resulting novel duplex form that results upon binding to it, is the basis for the GMS’s IP position.

GMSbiotech has also found a way to completely bypass DNA purification in its HLA-typing products: enabling routine HLA typing from a microliter (about 1/50th of a drop) of raw blood; or enabling HLA typing from about 1/10th of the dried blood in a single 2mm punch-out from a neonatal filter paper card; or enabling HLA typing from 1/50th of the rehydrated sample derived from an ordinary cheek swab. It makes sample collection for HLA typing as simple and inexpensive as possible, in a way that fits naturally into existing, large-scale public health sample collection schemes. In terms of work-flow, it cuts in half, the time and the number of steps required to perform such HLA typing. And finally in terms of cost, it completely eliminates the cost of DNA purification from HLA-typing, thus reducing the cost per HLA test by about 50%.

In the aggregate, this suite of HLA-typing technologies is designed to allow, for the first time, routine high-resolution HLA-typing at the population-scale, on raw samples, at an aggregate cost that has dropped to about 1/10th that of HLA-typing, as currently employed in solid organ transplantation.

GMSbiotech will also launch a Donor Specific Antibody screening "EZScreen™" & monitoring test. The GMSbiotech product line will feature HLA Class I & II native antibody detection for pre & post transplantation.















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